¿licopeno y fotoprotección?
PDF

Palavras-chave

Licopeno, carotenoides, fotoenvejecimiento de la piel Licopeno, carotenoides, fotoenvejecimiento de la piel

Como Citar

Quevedo Torres, K. L. ., Suzuki , V. ., Bernardes Fanaro, G. ., Fanaro de Oliveira, A. ., Torres Madeiro Leite, J. A., Mehlmann Namur, C. R. ., Rocha Oliveira, C., & Masako Ferreira, L. . (2020). ¿licopeno y fotoprotección?. Advances in Nutritional Sciences, 1(1), 80–88. https://doi.org/10.47693/ans.v1i1.17

Resumo

Introducción: El licopeno es uno de los pigmentos carotenoides encontrados en la naturaleza. Este pigmento carotenoide no posee actividad de pro vitamina A; sin embargo, tiene un efecto protector contra radicales libres, siendo considerado un potente antiozidante. Objetivo: compilar la información disponible sobre la ingesta de licopeno y su posible acción como fotoprotector en la piel humana. Material y Métodos: Se realizó una revisión bibliográfica en buscadores Medline, Lilacs y Scielo utilizando las palabras clave, licopeno, carotenoides y fotoenvejecimiento de la piel en portugués, inglés y español. Resultado: Para este estudio, se seleccionaron 265 artículos, 46 fueron incluidos y 219 fueron excluidos debido a que no cumplían con los criterios de elegibilidad. Conclusión: Los estudios expuestos en esta revisión demuestran que otros carotenoides, además del licopeno, tienen efecto fotoprotector. La fotoprotección ofrecida por la suplementación de licopeno es menor a la que ofrecen los protectores solares y por tanto no puede utilizarse como sustituto. Sin embargo, el conocimiento actual de las propiedades del licopeno puede servir en un futuro para desarrollar algún fotoprotector de administración oral.

https://doi.org/10.47693/ans.v1i1.17
PDF

Referências

Zhang H, Kotake-Nara E, Ono H, Nagao A. A novel cleavage product formed by autoxidation of lycopene induces apoptosis in HL-60 cells. Free Radic Biol Med. 2003;35(12):1653–63.

Cozzolino SMF. Biodisponibilidade de Nutrientes. 2º ed. atual e ampl. Barueri: Manole, 2007.

Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys. 1989;274(2):532-8.

Rao AV, Agarwal S. Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: a review. Nutr Res. 1999;19(2):305-23.

Shami NJIE, Moreira EAM. Licopeno como agente antioxidante. Rev Nutr. 2004;17(2):227-36.

Stahl W, Sies H. Lycopene: a biologically important carotenoid for humans?. Arch Biochem Biophys. 1996;336(1):1-9.

Böhm F, Edge R, Burke M, Truscott TG. Dietary uptake of lycopene protects human cells from singlet oxygen and nitrogen dioxide – ROS components from cigarette smoke. J Photochem Photobiol B. 2001;64(2-3):176–8.

Burri BJ, Nguyen T, Neidlinger TR. Absorption estimates improve the validity of the relationship between dietary and serum lycopene. Nutrition. 2010;26(1):82–9.

Weisburger JH. Lycopene and tomato products in health promotion. Exp Biol Med. 2002;227(10):924–7.

Aust O, Ale-Agha N, Zhang L, Wollersen H, Sies H, Stahl W. Lycopene oxidation product enhances gap junctional communication. Food Chem Toxicol. 2003;41(10):1399–407.

Zhang LX, Cooney RV, Bertran JS. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/ 10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenesis. 1991;12(11):2109–14.

Pastori M, Pfander H, Boscoboinik D, Azzi A. Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. Biochem Biophys Res Commun. 1998;250(3):582–5.

Astorg P, Gradelet S, Berges R, Suschetet M. Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat. Nutrit Cancer. 1997;29(1):60–8.

Bhuvaneswari V, Nagini, S. Lycopene: a review of its potential as an anticancer agent. Curr Med Chem Anticancer Agents. 2005;5(6):627–35.

Scolastici C, Alves de Lima R.O, Barbisan LF, Ferreira ALA, Ribeiro DA, Salvadori DMF. Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test. Toxicol in Vitro. 2008;22(2):510–4.

Stahl W, Sies H. B-Carotene and other carotenoids in protection from sunlight. Am J Clin Nutr. 2012;96(5):1179-84

Moritz B, Tramonte VLC. Biodisponibilidade do licopeno. Rev Nutr. 2006;19(2):265-73.

Ried K, Fakler P. Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials. Maturitas. 2011;68(4):299–310.

Schalka S, Steiner D, Ravelli FN, Steiner T, Terena AC, Marçon CR, Ayres EL, Addor FAS, Miot HA, Ponzio H, Duarte I, Neffá J, Cunha JAJ, Boza JC, Samorano LP, Corrêa MP, Maia M, Nasser N, Leite OMRR, Lopes OS, Oliveira PD, Meyer RLB, Cestari T, Reis VMS, Rego VRPA. Brazilian consensus on photoprotection. An Bras Dermatol. 2014;89(6):1-74.

Ford NA, Erdman Jr JW. Are lycopene metabolites metabolically active? Acta Biochim Pol. 2012;59(1):1-4.

Graham DL, Carail M, Caris-Veyrat C, Lowe GM. Cigarette smoke and human plasma lycopene depletion. Food Chem Toxicol. 2010;48(8-9):2413–20.

Lambelet P, Richelle M, Bortlik K, Franceschi F, Giori AM. Improving the stability of lycopene Z-isomers in isomerised tomato extracts. Food Chem. 2009;112(1):156–61.

Böhm V, Puspitasari-Nienaber NL, Ferruzzi MG, Schwartz SJ. Trolox equivalent antioxidant capacity of different geometrical isomers of alphacarotene, beta-carotene, lycopene, and zeaxanthin. J Agric Food Chem. 2002;5(1):221–6.

Burri BJ, Neidlinger TR, Clifford AJ. Serum carotenoid depletion follows first order kinetics in healthy adult women fed naturally low carotenoid diets. J Nutr 2001;131(8):2096–101.

Ahuja KDK, Pittaway JK, Ball MJ. Effects of olive oil and tomato lycopene combination on serum lycopene, lipid profile, and lipid oxidation. Nutrition. 2006;22(3):259–65.

Faulk RM, Southon, S. Challenges to understanding and measuring carotenoid bioavailability. Biochim. Biophys. Acta. 2005;1740(2):95-100.

National Academy of Sciences. Dietary reference intakes: the essential guide to nutrient requirements. The National Academies Press: Washington, D.C., 2006.

Colle IJP, Van Buggenhout S, Lemmens L, Van Loey A.M, Hendrickx, ME. The type and quantity of lipids present during digestion influence the in vitro bioaccessibility of lycopene from raw tomato pulp. Food Res Int. 2012;45(1):250–5.

Chen J, Shi J, Xue SJ, Mac Y. Comparison of lycopene stability in water- and oil-based food model systems under thermal- and light-irradiation treatments. Food Sci Technol. 2009;42(3):740-7.

Boileau TWM, Boileau AC, Erdman JW. Bioavailability of all-trans and cis-isomers of lycopene. Exp Biol Med. 2002;227(10):914–19.

Heredia A, Peinado I, Rosa E, Andrés A. Effect of osmotic pre-treatment and microwave heating on lycopene degradation and isomerization in cherry tomato. Food Chem. 2010;123(1):92–8.

Shi J, Dai Y, Kakuda Y, Mittal G, Xue SJ. Effect of heating and exposure to light on the stability of lycopene in tomato purée. Food Control. 2008;19(5):514–20.

Riso P, Brusamolino A, Contino D, Martini D, Vendrame S, Del Bo’ C, Porrini M. Lycopene absorption in humans after the intake of two different single-dose lycopene formulations. Pharmacol Res. 2010;62(4):318–21.

Goñi I, Serrano J, Saura-Calixto F. Bioaccessibility of β-carotene, lutein, and lycopene from fruits and vegetables. J Agric Food Chem. 2006;54(15):5382-7.

Rao AV, Rao LG. Carotenoids and human health. Pharmacol Res. 2007;55(3): 207–16.

Farias RG, Santos SMA. Influência dos determinantes do envelhecimento ativo entre idosos mais idosos. Texto & Contexto Enferm. 2012;21(1):167-76.

Scharffetter–Kochanek K, Brenneisen P, Wenk J, Herrmann G, Ma W, Kuhr L, Meewes C, Wlaschek M. Photoaging of the skin from phenotype to mechanisms. Exp Gerontol. 2000;35(3):307–16.

Wlaschek M, Tantcheva-Poór I, Naderi L, Ma W, Schneider LA, Razi-Wolf Z, Schüller J, Scharffetter-Kochanek K. Solar UV irradiation and dermal photoaging. J Photochem Photobiol B. 2001;63(1-3):41–51.

Zotarelli ML, Falcão MC. Guias alimentares adaptados à faixa etária infantil. Rev Bras Nutr Clin. 2007;22(3):237-42.

Araujo TS, Souza SO. Protetores solares e os efeitos da radiação ultravioleta. Scientia Plena. 2008;4(11):1-7.

Darvin M, Patzelt A, Gehse S, Schanzer S, Benderoth C, Sterry W, Lademann J. Cutaneous concentration of lycopene correlates significantly with the roughness of the skin. Eur J Pharm Biopharm. 2008;69(3):943–7.

Krutmann J. Ultraviolet A radiation-induced biological effects in human skin: relevance for photoaging and photodermatosis. J Dermatol Sci. 2000;23(1):22–6.

Aust O, Stahl W, Sies H, Tronnier H, Heinrich U. Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema. Int J Vitam Nutr Res. 2005;75(1):54-60.

Basu-Modak S, Tyrrell RM. Singlet oxygen: a primary effector in the ultraviolet A/near-visible light induction of the human heme oxygenase gene. Cancer Res. 1993;53(19):4505–10.

Ferreira T, Pinheiro L, & Catucci J. Acquired hyperpigmentations. Anais Brasileiros de Dermatologia. 2014;89(1):11–25.

Offord EA, Gautier JC, Avanti O, Scaletta C, Runge F, Krämer K, Applegate LA. Photoprotective potential of lycopene, β-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radic Biol Med. 2002;32(12):1293–303.

Scarmo S, Cartmel, B, Lin A, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST. Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults. Arch Biochem. Biophys. 2010;504(1):34–9.

Pongcharoen S, Warnnissorn P, Lertkajornsin O, Limpeanchob N, Sutheerawattananonda M. Protective effect of silk lutein on ultraviolet B-irradiated humankeratinocytes. Biol Res. 2013;46(1):39-45.

Böhm F, Edge R, Truscott TG. Interactions of dietary carotenoids with xinglet oxygen (O2) and free radicals: potential effects for human health. Acta Biochimica Polonica, Acta Biochim Pol. 2012;59(1):27-30.

Marini A, Jaenicke T, Grether-Beck S, Le Floc'h C, Cheniti A, Piccardi Krutmann J. Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, B-carotene, and Lactobacillus johnsonii: results from a randomized, placebo-controlled, double-blinded study. Photodermatology, Photodermatol Photoimmunol Photomed. 2014;30(4)189-94.

Meinke M, Friedrich A, Tscherch K, Haag S, Darvin M, Vollert H, Groth N, Lademann J, Rohn S. Influece of dietary carotenoids on radical scavenging capacity of the skin and skin lipids. Eur J Pharm Biopharm. 2013;84(2):365-73.

Stahl W, Sies H. Photoprotection by dietary carotenoids: Concept, mechanism, evidence and future development. ol Nutr Food Res. 2012;56(2):287-95.

Rizwan M, Rodriguez-Blanco I, Harbottle A, Birch-Machin M, Watson R, Rhodes L. Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. Br J Dermatol. 2011;164(1):154-62.

Césarini JP, Michel L, Maurette JM, Adhoute H, Béjot M. Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatol Photoimmunol Photomed. 2003;19(4):182–9.

Stahl W, Heinrich U, Wiseman S, Eichler O, Sies H, Tronnier H. Dietary tomato paste protects against ultraviolet light–induced erythema in humans. J Nutr. 2001;131(5):1449-51.

Couto M, Souza J. Physicochemical changes in cubiu fruits (Solanum sessiliflorum Dunal) at different ripening states. Ciência e Tecnologia de Alimentos 2012;32(2):250-4.

Cipriani MA, Campos RV, Coutinho J, Moretti TA, Tiraboschi N. The vegetal biomembrane in the healing of chronic venous ulcers. An. Bras. Dermatol. 2012;87(1):45-51.

Rao AV, Agarwal S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr Cancer. 1998;31(3):199–203.

Shao A, Hathcock JN. Risk assessment for the carotenoids lutein and lycopene. Regul Toxiol Pharmacol. 2006;45(3):289–98.

Olmedilla B, Granado F, Southon S, Wright AJ, Blanco I, Gil-Martinez E, van den Berg H, Thurnham D, Corridan B, Chopra M, Hininger I. A European multicentre, placebo-controlled supplementation study with alpha-tocopherol, carotene-rich palm oil, lutein or lycopene: analysis of serum responses. Clin Sci. 2002;102(4):447–56.

Jonker D, Kuper CF, Fraile N, Estrella A, Otero CR. Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats. Regul Toxiol Pharmacol. 2003;37(3):396–406.

Mellert W, Deckardt K, Gembardt C, Schultea S, Van Ravenzwaay B, Slesinski RS. Thirteen-week oral toxicity study of synthetic lycopene products in rats. Food Chem Toxicol. 2002;40(11):1581–88.

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

Copyright (c) 2020 Kathia Larissa Quevedo Torres, Vanessa Suzuki , Gustavo Bernardes Fanaro, Adriana Fanaro de Oliveira, Jorge Alberto Torres Madeiro Leite, Clinton Raphael Mehlmann Namur, Carlos Rocha Oliveira, Lydia Masako Ferreira